Radiation Therapy for Prostate Cancer
Radiation therapy uses high-powered energy to kill cancer cells. Prostate cancer radiation therapy
to treat the prostate gland can be delivered in the following ways:
- External beam radiation: You lie on a table while a machine moves around your body,
directing high-powered energy beams to the site of the prostate cancer. Treatment is
traditionally given 5 days a week for 6−8 weeks. However, shorter courses of radiation may
be used. - Brachytherapy: Using a needle guided by ultrasound, your doctor places many rice-sized
radioactive seeds in your prostate tissue. The seeds deliver a low-dose of radiation over a
long period of time. - High-dose rate (HDR) brachytherapy: Your doctor places tiny hollow catheters (thin, flexible
tubes) into the prostate and then places radioactive seeds into the catheters. - Radioligand therapy (RLT): Your doctor injects a special medicine that goes straight to the
cancer cells and delivers a targeted dose of radiation from inside the body. This approach
damages or destroys cancer cells while limiting harm to healthy cells. It is currently used
for advanced prostate cancer.
These are the RLT drugs that are used most often to treat prostate cancer. New treatments
become available all the time, so this may not be a complete list.
Please note: The side effects listed here do not represent a comprehensive list. Each RLT drug has
its own set of side effects and ways of working. It's important to discuss all potential side effects of
a drug with your healthcare team. Be sure to tell your healthcare team about any side effects you do
have.
All Available Treatments
IV (through a vein) =
Pill = 
Treatment Type
Radioligand therapy
Drug Names
(Radium-223) Xofigo® (IV)
(Lutetium Lu 177 vipivotide tetraxetan) Pluvicto® (IV)
Potential Side Effects
Fatigue/weakness
Hair thinning/loss
Nausea/vomiting
Weight/appetite changes
Urinary, kidney, or bladder changes
Skin/nail changes
Mouth/throat changes
Gastrointestinal problems
Joint pain/stiffness
Low blood counts
Important Things to Know
- After RLT, your body may emit, or give off, a small amount of radiation for a short time
(around 3 days). Because of this, there are special safety steps you need to follow after
each session. - Staying hydrated after your RLT infusion can help with side effects.
- Low blood counts may put you at risk for anemia, infection, or bleeding.
- Treatment can cause temporary hair loss, but hair usually grows back after treatment.
- Your healthcare team will monitor you for side effects and may adjust doses if needed.
- Some side effects like nausea or skin changes can often be managed with medications or
diet changes.