Radiation Therapy for Prostate Cancer

Radiation therapy uses high-powered energy to kill cancer cells. Prostate cancer radiation therapy 
to treat the prostate gland can be delivered in the following ways: 

  • External beam radiation: You lie on a table while a machine moves around your body, 
    directing high-powered energy beams to the site of the prostate cancer. Treatment is 
    traditionally given 5 days a week for 6−8 weeks. However, shorter courses of radiation may 
    be used.
  • Brachytherapy: Using a needle guided by ultrasound, your doctor places many rice-sized 
    radioactive seeds in your prostate tissue. The seeds deliver a low-dose of radiation over a 
    long period of time.
  • High-dose rate (HDR) brachytherapy: Your doctor places tiny hollow catheters (thin, flexible 
    tubes) into the prostate and then places radioactive seeds into the catheters.
  • Radioligand therapy (RLT): Your doctor injects a special medicine that goes straight to the 
    cancer cells and delivers a targeted dose of radiation from inside the body. This approach 
    damages or destroys cancer cells while limiting harm to healthy cells. It is currently used 
    for advanced prostate cancer. 

These are the RLT drugs that are used most often to treat prostate cancer. New treatments 
become available all the time, so this may not be a complete list. 
 

Please note: The side effects listed here do not represent a comprehensive list. Each RLT drug has 
its own set of side effects and ways of working. It's important to discuss all potential side effects of 
a drug with your healthcare team. Be sure to tell your healthcare team about any side effects you do 
have. 

Expand

All Available Treatments

IV (through a vein) =      Pill =

Treatment Type

Radioligand therapy

Drug Names
(Radium-223) Xofigo® (IV)
(Lutetium Lu 177 vipivotide tetraxetan) Pluvicto® (IV)
Important Things to Know
  • After RLT, your body may emit, or give off, a small amount of radiation for a short time 
    (around 3 days). Because of this, there are special safety steps you need to follow after 
    each session. 
  • Staying hydrated after your RLT infusion can help with side effects. 
  • Low blood counts may put you at risk for anemia, infection, or bleeding. 
  • Treatment can cause temporary hair loss, but hair usually grows back after treatment. 
  • Your healthcare team will monitor you for side effects and may adjust doses if needed. 
  • Some side effects like nausea or skin changes can often be managed with medications or 
    diet changes.